Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Furthermore, this diplotype was associated with low-renin (LR) hypertension (identifying 32% of the LR hypertensives), higher plasma aldosterone, and lower plasma renin and serum potassium levels.
|
17015767 |
2006 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Prenatal LPS exposure increased blood pressure, Ang II expression, Ang II-positive, monocyte and lymphocyte, apoptotic cells in the kidney, and induced renal histological changes in offspring; however, the LPS and control groups did not differ significantly with respect to plasma renin activity levels, Ang II levels, or renal function.
|
28992100 |
2017 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Renin-angiotensin system inhibitors, specifically angiotensin II converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB), have confirmed renoprotective benefits in patients with proteinuria and hypertension.
|
29310811 |
2018 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
The aim of this study was to examine the level of total cholesterol, LDL cholesterol, VLDL cholesterol, HDL cholesterol, uric acid, glycemia, aldosterone, and plasma renin activity in a population of 42 young, slender normotensive subjects with positive family history of hypertension (FH+) or negative family history of hypertension (FH-).
|
9322993 |
1997 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Sodium and volume excess is the prominent mechanism of hypertension in dialysis patients, but other pathways, such as arterial stiffness, activation of the renin-angiotensin-aldosterone and sympathetic nervous systems, endothelial dysfunction, sleep apnea and the use of erythropoietin-stimulating agents may also be involved.
|
28157814 |
2017 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Although inconclusive, current evidence suggests that the renin-angiotensin system may be involved in hypertension.
|
20537141 |
2010 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Low plasma renin activity was associated with the development of hypertension in the middle-aged Asian population, especially in peoples with high sodium intake.
|
29902069 |
2019 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Excess aldosterone leads to arterial hypertension with suppressed renin, frequently associated to hypokalemia.
|
31397984 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Levosimendan improves cardiac function and survival in rats with angiotensin II-induced hypertensive heart failure.
|
20811386 |
2010 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
One factor that appears to play an important role in programming for hypertension in adulthood is maternal dietary protein restriction during pregnancy, possibly by suppression of the fetal renin-angiotensin system and consequent impairment of renal development.
|
10192254 |
1999 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The renin-angiotensin-aldosterone system (RAAS) helps maintain blood pressure and salt homeostasis and appears important in the pathogenesis of hypertension and some forms of vascular disease.
|
10685727 |
2000 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The renin-angiotensin-aldosterone system (RAAS) and its polymorphisms apparently confer a genetic risk for uncontrolled AHT.
|
21471972 |
2011 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Renin-Angiotensin-Aldosterone Profiles in Pregnant Women With Chronic Hypertension.
|
29941520 |
2018 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The genes in the renin-angiotensin system are important physiologic candidates in studies of the genetic susceptibility to hypertension.
|
14970846 |
2004 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Our results parallel earlier observed gender differences of the relationship between other renin-angiotensin system polymorphisms and HTN.
|
19274051 |
2010 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Gene polymorphisms of the renin-angiotensin system and age-related changes in systolic and diastolic blood pressure in subjects with hypertension.
|
15062885 |
2004 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
To investigate whether genetic variation in the renin-angiotensin-aldosterone system (RAAS) and kallikrein-bradykinin pathways is related to hypertension and blood pressure (BP) response to angiotensin-converting enzyme (ACE) inhibitor therapy in stable coronary artery disease (CAD) patients.
|
21157371 |
2011 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The renin-angiotensin-aldosterone system: a crossroad from arterial hypertension to heart failure.
|
31512149 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Impact of renin-angiotensin-aldosterone system genes on the treatment response of patients with hypertension and metabolic syndrome.
|
18205097 |
2007 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Three of the loci are in the renin-angiotensin-system, angiotensinogen, ACE, and angiotensin II type 1 receptor, and they have been associated with hypertension in at least 1 previous study.
|
10904004 |
2000 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Aliskiren, a direct renin inhibitor, has shown potent ability to attenuate hypertension.
|
27809355 |
2017 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
This review discusses the impact of the availability of these clones in three clinically relevant areas--the role of the renin-angiotensin system in hypertension, the role of tissue renin-angiotensin systems, and the development of renin inhibitors.
|
1725015 |
1991 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Plasma norepinephrine levels, but not plasma renin activity, aldosterone, epinephrine, or vasopressin levels, were significantly higher in the hypertension with compression group (389+/-53 pg/ml) than in the hypertension without compression group (217+/-38, P<0.05) or in the normotension group (225+/-30, P<0.05).
|
10608471 |
1999 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
LHGDN |
Rats harboring the human renin and angiotensinogen genes (dTGR) feature angiotensin (ANG) II/hypertension-induced cardiac damage and die suddenly between wk 7 and 8.
|
17416596 |
2007 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
This feature distinguishes this form of hypertension from glucocorticoid remediable aldosteronism and Liddle's syndrome, which are salt-sensitive forms of monogenic hypertension with very low plasma renin activity.
|
8673114 |
1996 |